Sideroblastic Anemia Diagnosis

siderblastic-anemia-diagnosisSideroblastic anemia is one of the principal types of iron-utilization anemias.  Abnormal, iron-saturated red cells are present in the blood of people who have this disease.  Although the iron circulates normally from the plasma to the bone marrow, where new red blood cells are created, it is not properly incorporated into new red blood cells.

Hereditary Sideroblastic Anemia. The hereditary form is an X-linked recessive trait with variable expression.  Hereditary sideroblastic anemias are usually small (microcytic) and of poor color (hypochromic) and thus must be distinguished from iron deficiency and thalassemia.

Acquired Sideroblastic Anemia. Acquired sideroblastic anemia may be cured when the condition that causes it is treated or removed.  If the cause of a patient’s anemia cannot be determined, blood transfusions may be necessary.  Medications are prescribed to stimulate excretion or excess iron that accumulates as a result of these transfusions.
Causes and Development
Sideroblastic anemia is also associated with:

Lymphoma ( cancer of the lymph glands)
Myeloma (cancer of the bone marrow)
Rheumatoid arthritis
Other inflammatory diseases.

Signs and Symptoms
Symptoms of sideroblastic anemia are the same as symptoms of the disease that causes the condition, as well as anemia.
Possible complications of sideroblastic anemia include:

Congestive heart failure
Diabetes mellitus
Enlargement of the liver and spleen
Formation of liver nodules and scar tissue
Irregular heartbeat
Recurring inflammation of the sac that surrounds the heart
Secondary hypopituitarism (dwarfism)
Skin darkening
Underactivity of the thyroid gland (hypothyroidism).

Sideroblastic anemia of unknown origin may lead to leukemia.  It may take as long as 10 years for this disease progression to take place.